The Dickinson Lab
Cell Polarity happens when two ends of a living cell become molecularly distinct from each other. Cell polarity is crucial for proper function of almost every cell in the human body. We work to understand how cell polarity is generated in normal cells, and how it is disrupted in diseases including cancer.
We employ a multi-disciplinary approach including single-molecule biochemistry, genome editing, microfluidics, fluorescence microscopy of living cells, and quantitative image analysis. We work mainly with embryos of the nematode worm C. elegans but are expanding our work into mammalian cell culture systems. If the tool we need to answer a scientific question doesn't exist, we invent it.